Fig. 5.

Internalization of AMPA receptors following the application of NMDA is impaired in SJ1-KO neurons. (A) Time traces of pH-GluR2 fluorescence in WT and SJ1-KO neurons in response to a 5-min NMDA application. (B) Time course of pH-GluR2 fluorescence in the fields shown in A. (C) Average reduction of the pH-GluR2 fluorescence signal in dendrites of WT and SJ1-KO neurons at the end of the 5-min NMDA application. The decrease in fluorescence intensity is lower in mutant neurons.