Representative clusters with solved multidomains SP-chains. The geometrical symbols represent different folds within each cluster. The numbers indicate the occurrence of a specific fold combination among the solved SP-chain in that cluster. In all of the examples, the representative fold is indicated by a rectangle. Clusters illustrated in the scheme are: cluster 10, trypsin proteases; cluster 44, α and β amylases; cluster 50, pyridine nucleotide-disulphide oxidoreductases; cluster 171, endochitinases; and cluster 462, shiga/ricin ribosomal inactivating toxins.