Table 3. Numbers of genes changing expression with hyperoxia.
|
Time in hyperoxia |
|||
|---|---|---|---|
| 3 days | 7 days | 14 days | |
| Increased expression |
509 |
967 |
933 |
| Decreased expression |
668 |
1426 |
2169 |
| Total genes changing expression |
1177 |
2393 |
3102 |
| ANOVA |
18 |
19 |
95 |
| Retinal Disease Genes |
0 |
0 |
15 |
| GO: Response to stress |
58 |
108 |
196 |
| GO: Apoptosis-related | 45 | 81 | 101 |
The number of genes regulated by hyperoxia, over a 14 day exposure, with a change of ±2 fold or greater is shown. The data were further analyzed and divided into catagories based on several criteria, including gene increases (first row), decreases (second row), total number of gene changes (third row), number of genes with a p<0.05 (ANOVA; fourth row) and genes associated with human retinal diseases (fifth row). Using Gene Ontology (GO), those genes associated with stress (sixth row) and apoptotic cell death (seventh row) were also determined.