Figure 3.

Activation of spinal CRF₂ receptors significantly enhances VMRs evoked by UBD. A: I.t. administration of the CRF₂ receptor agonist, urocortin 2, but not the CRF₁ receptor agonist, CRF, significantly increased bladder nociceptive responses relative to i.t. administration of vehicle (* and ** indicate significantly different from vehicle at p<0.05 and p<0.01, respectively). B: I.p. administration of the same CRF receptor agonists at the same i.t. doses did not affect EMG responses. N=5-8/group