A: I.t. administration of the CRF2 receptor antagonist, aSVG30, significantly attenuated the augmentation of bladder nociceptive responses induced by urocortin 2 (** indicates significant difference from aSVG30 + urocortin 2 and from aSVG30 + vehicle at p<0.01). B: In contrast, i.t. administration of the CRF1 receptor antagonist, antalarmin, had no effect on UBD-evoked VMRs. N=5-8/group.