Fig. 2.

COX-2 inhibitor NS-398 enhances mIPSCs in the hippocampus. (a) Representative sweeps of mIPSCs in the absence or presence of NS-398. mIPSCs were recorded in hippocampal CA3 pyramid neurons. The membrane potential was held at −70 mV. D-APV (400 μmol/L), NBQX (10 μmol/L), and TTX (0.5 μmol/L) were included in the external solution. The synaptic events were analyzed with Clampfit 9; (b) Cumulative probability of mIPSC amplitude in the absence or presence of NS-398. Mean percentage changes (normalized to the baseline) in the presence of NS-398; (c) The decay-time constant of mIPSC (Table 1). The decay time increased from (122±6)% (P=0.002) with 10 μmol/L NS-398 to (235±22)% (P=0.0001) with 30 μmol/L NS-398; (d) The frequency of mIPSC. The frequency of mIPSC (Table 1) increased from (120±5)% (P=0.008) with 10 μmol/L NS-398 to (194±19)% (P=0.0001) with 30 μmol/L NS-398. ^*A significant change between mean±SEM