Table 1.

P-values for the associations between each GHSR htSNP and body size in children (ALSPAC) and adults (Ely and EPIC5000 studies).

		GHSR htSNPs
		G477A	T171C	C447G
		rs572169	rs495225	rs2232169
Children		P-value	P-value	P-value
ALSPAC (N=843)	Height	0.66	0.22	0.62
	Weight	0.29	0.88	0.62
	BMI	0.20	0.64	0.94
	IGF-I	0.16	0.64	0.40
Adult cohorts		P-value	P-value	P-value
Ely Study (N=811)	Height	0.36	0.20	0.51
	Weight	0.52	0.014 (+ve)	0.83
	BMI	0.67	0.041 (+ve)	0.16
	IGF-I	0.015 (+ve)	0.70	0.11
EPIC5000 (N=4996)	Height	0.035 (-ve)	0.97	0.47
	Weight	0.15	0.83	0.51
	BMI	0.54	0.69	0.18
Combined adult cohorts		P-value	P-value	P-value
EPIC5000 + Ely* (N=5,807)	Height	0.11	0.69	0.63
	Weight	0.30	0.26	0.83
	BMI	0.72	0.25	0.47

Analyses are adjusted for age and gender.

^*Additionally adjusted for study population (EPIC5000 or Ely Study)

p-values are from co-dominant (additive) models.

Where p<0.05, “+ve” or “-ve” indicate the direction of association with minor allele copy number