Table 3.

Sample Recommendations^* for Transition From IV to SC Insulin Therapy

Administer first SC dose (basal insulin) at least 2 hrs prior to terminating IV infusion TDD for first SC administration is 80% of estimated 24-hr insulin requirement Subsequent doses over next few days are adjusted according to patient response and improving health until ○ Basal dose is ∼50% of SC TDD ○ Bolus total dose is ∼50% of SC TDD Correction dose is determined as ○ Actual BG minus target BG divided by the CF (CF is 1700 divided by TDD)

^*Unvalidated, no clinical trials have tested any transition strategies.

BG = blood glucose; CF = correction factor, representing the BG reduction associated with 1 U of rapid-acting insulin; IV = intravenous; SC = subcutaneous; TDD = total daily dose

Adapted with permission from Bode BW, Braithwaite SS, Steed RD, Davidson PC. Endocr Pract. 2004;10(suppl 2):71–80.[34]