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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Nat Immunol. 2008 Sep 21;9(11):1279–1287. doi: 10.1038/ni.1653

Figure 3.

Figure 3

Irgm1 promotes cell survival during pathogen-driven TH1 responses and prevents IFN-γ-dependent mortality in mycobacteria-infected mice. (a) Survival of CD4+ T cells in vivo. CD45.2+Ifng–/– (open symbols) or Irgm1–/–Ifng–/– (closed symbols) CD4+ lymphocytes pre-activated with agonistic CD3 mAb in vitro were transferred i.p. into congenic CD45.1+ C57BL/6.SJL recipients that were left untreated or inoculated i.p. with T. gondii or M. avium 3 days earlier. Percentage of donor CD4+ T cells in PEC collected at day 4 after transfer was determined by flow cytometry. (b) Survival of M. avium infected WT or KO mice (n = 5 per genotype) was monitored through the course of infection. (c) Splenic bacterial loads, (d) circulating and (e) splenic lymphocyte numbers were determined at wk4 after M. avium infection (n = 5). Data shown are representative of two independent experiments with each symbol representing an individual mouse.