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. Author manuscript; available in PMC: 2008 Nov 6.
Published in final edited form as: Biochemistry. 2007 Mar 24;46(15):4522–4531. doi: 10.1021/bi0622468

FIGURE 8.

FIGURE 8

Molecular model of CCK bound to the type A CCK receptor. Shown are lateral (left) and top (right) views of the lowest energy molecular model of CCK bound to the CCK receptor. The receptor amino-terminal domain is illustrated in brown, while the rest of the receptor is green. The peptide ligand, CCK-8, is shown as a stick model with transparent surface skin in white. Key residues of interest have been highlighted. These include receptor residues Asp5 and Lys187 that are involved in charge-pairing, Cys pairs that are involved in disulfide bonds (Cys18-Cys29 and Cys114-Cys196), and three sites of N-linked glycosylation (Asn10, Asn13, and Asn24). The TM helices have been identified in the top view.