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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Neuropsychopharmacology. 2008 Feb 27;33(12):2946–2956. doi: 10.1038/npp.2008.10

Figure 3.

Figure 3

Pretreatment (PRE) with methylphenidate (MP 1; 1.0 mg/kg, s.c., once daily for 5 consecutive days) did not alter the effectiveness of methylphenidate (TEST) to suppress social play. (a) Effect of 1.0 mg/kg methylphenidate, s.c. (MP 1), or saline (SAL) on pinning after 5 days of pretreatment with methylphenidate (1.0 mg/kg, s.c.; MP 1) or saline (SAL) (F(pretreatment)1,31=1.57, NS; F(treatment)1,31=33.73, p<0.0001; F(interaction)1,31=2.13, NS). (b) Effect of 1.0 mg/kg methylphenidate, s.c. (MP 1), or saline (SAL) on pouncing after 5 days of pretreatment with methylphenidate (1.0 mg/kg, s.c.; MP 1) or saline (SAL) (F(pretreatment)1,31=0.34, NS; F(treatment)1,31=48.10, p<0.0001; F(interaction)1,31=2.61, NS). (c) Effect of 0.1 mg/kg methylphenidate, s.c. (MP 0.1), or saline (SAL) on pinning after 5 days of pretreatment with methylphenidate (1.0 mg/kg, s.c.; MP 1) or saline (SAL) (F(pretreatment)1,31=0.002, NS; F(treatment)1,31=0.41, NS; F(interaction)1,31=1.43, NS). (d) Effect of 0.1 mg/kg methylphenidate, s.c. (MP 0.1), or saline (SAL) on pouncing after 5 days of pretreatment with methylphenidate (1.0 mg/kg, s.c.; MP 1) or saline (SAL) (F(pretreatment)1,31=1.36, NS; F(treatment)1,31=0.008, NS; F(interaction)1,31=0.09, NS). *Significantly different from SAL/SAL (pretreated with saline, tested after saline) rats, p<0.05 (Student-Newman-Keuls test); #significantly different from MP 1/SAL (pretreated with methylphenidate, tested after saline) rats, p<0.05 (Student-Newman-Keuls test).