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. 2008 Sep 16;17(23):3740–3760. doi: 10.1093/hmg/ddn271

Figure 6.

Figure 6.

(A) Graph denotes the Absolute Enrichment (NES = 1.541, P < 0.001) of the gene set containing those genes whose expression increased in the subpallium in the absence of Arx and were enriched in interneurons within a subset of the Marsh et al. data set (genes expressed in GFP+ subpallial cells versus those expressed in GFP+ cortical cells FAC sorted from Dlx5/6Cre-IRES-eGFP mice) (left). Green boxes contain those genes deemed as enriched (right). The genes contained within the top box are those genes whose expression increased in the subpallium of Arx mutant mice and were enriched in GFP+ interneurons within the cortex. The lower box contains genes whose expression increased in the subpallium of the Arx mutant mouse and were enriched in GFP+ neurons that remain within the subpallium. To validate the predicted expression data, in situ hybridization images of E14.5 embryonic brain were downloaded from the GenePaint web site (53) for (B) Kitl, (C) Sst, (D) Phlda1, (E) AI427515, (F) Hap1, (G) Magel2, (H) Lbxcor1 and (I) Gbx2. (J) Graph denotes the Absolute Enrichment (NES = 1.605, P < 0.001) of the gene set containing those genes whose expression decreased in the subpallium in the absence of Arx and were enriched in Dlx5/6-derived cells within a subset of the Marsh et al. data set (genes expressed in GFP+ subpallial cells versus those expressed in GFP+ cortical cells FAC-sorted from Dlx5/6Cre-IRES-eGFP mice) (left). Green boxes contain those genes deemed as enriched (right). The genes contained within the top box are those genes whose expression decreased in the subpallium of Arx mutant mice and were enriched in GFP+ interneurons within the cortex. The lower box contains genes whose expression decreased in the subpallium of the Arx mutant mouse and were enriched in GFP+ neurons that remain within the subpallium. To validate the predicted expression data, in situ hybridization images of E14.5 embryonic brain were downloaded from the GenePaint web site for (K) Cxcr4, (L) Mef2c, (M) Sox8, (N) Zfp503 and (O) Ebf1.