Figure 4.

Effect of LXR-agonist treatment on maternal–fetal cholesterol transfer. Placental gene expression in C57Bl/6-mice treated with LXR-agonist. Fold change in mRNA expression compared with the mean control value. Controls: n = 18, six pups from three litters; LXR-treated: n = 24, six pups from four litters. (A) *Abca1, P < 0.0001; (B) *Abcg1, P < 0.0001, both unpaired t-test. Values are percent of mean for the controls. (C) The effect of LXR-agonist treatment on ¹⁴C-cholesterol transfer from mother to fetus. Values are ¹⁴C-cholesterol in fetuses in relation to ¹⁴C-cholesterol in maternal blood on E 16.5 and standardized to mean of controls. Controls: n = 6 from two litters; TO901317 treated: n = 9 from three litters, *P = 0.005, unpaired t-test.