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Enzymatic Activity and Nucleic Acid Binding of Novel IMPDH1 Variants Identified in This Study
| Specific Enzyme Activity (μmoles NADH/ min-mg) | Nucleic Acid Binding |
||
|---|---|---|---|
| Variant | Kd (nM) | Maximum % Bound | |
| Wild-type | 0.6 ± 0.2 | 6 ± 1 | 7 ± 0.4 |
| Arg105Trp | 0.9 ± 0.4 | > 50 | > 20 |
| Asn198Lys | 0.9 ± 0.3 | > 73 | > 25 |
| Thr116Met | 1 ± 0.3 | 100 ± 20 | 16 ± 2 |
| Gly324Asp | 1 ± 0.3 | 6 ± 1 | 8 ± 0.3 |
| His372Pro | 1 ± 0.5 | 12 ± 1 | 30 ± 1 |
