Fig. 1.
(A) Protein sequence of Aipl1, indicating high degree of sequence conservation extending across the protein, outside of the proline-rich region present only at the C-terminus of primate Aipl1. Identical residues across all eight species are indicated with an asterisk. Residues with only conservative substitutions are indicated with a period. (B) Unrooted cladogram indicating the relationship of AIPL1 to the FK506-binding protein (FKBPs) and cyclophilin families of the human immunophilin proteins. Protein sequences used (GenBank number): cyclophilin A (P04374), cyclophilin B (P23284), cyclophilin C (NP_000934), cyclophilin 40 (BAA09923), FKBP12 (P20071), FKBP51 (Q13451), FKBP52 (Q02790), AIP (O00170), AIPL1 (AAF26708).