Figure 4.

Human IMPDH1 transcripts and proteins. (A) Genomic structure and three IMPDH1 transcripts originally reported by Gu et al.¹⁷ Data suggested that all three transcripts encoded the canonical IMPDH1 protein shown on the right. (B) Observed retinal transcripts and predicted proteins. Transcripts α and β are from the exon 1F to 3′UTR R product subcloning. Transcripts γ, δ, and ε are from the exon A F to 3′UTR R product subcloning. Transcript percentages reflect results of separate subcloning experiments. Only transcripts seen in greater than 2% of clones from each subcloning experiment are reported. Green: novel protein regions from exon A. Red: residues resulting from exon 13b.