Scheme 1.
A. Synthesis of Trimethylene Inter-strand Cross-links of the Type N2-dG-(CH2)3-N2-dG (42). B. The Nucleophilic Aromatic Substitution Reaction of (S)-1,3-Diaminobutane with Excess O6-(2-Trimethylsilyl)-2-fluoroinosine Nucleoside.
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