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Neural antigen-induced secretion of IFNγ and IL-17 from Stat4α and β transgenic spleen cells in culture. Spleen cells were isolated from C57BL/6 wild type (WT), Stat4α transgenic (Stat4α) and Stat4β transgenic (Stat4β) mice on day 14 following induction of EAE. The cells were cultured with MOGp35–55 or Con A for 36 h, and the release of IFNγ (A) and IL-17 (B) was analyzed by ELISA.
