Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of PAR2 activation. Xenopus oocytes were injected with cRNAs encoding wild-type or mutant TF and/or PAR2, and agonist-triggered 45Ca2+ mobilization was measured. Representative experiments (mean ± SD, n = 3) are shown. (A) FVIIa-induced responses in oocytes expressing PAR2 with or without wild-type or mutant TF. (B) Responses in oocytes expressing PAR2 or the PAR2 cleavage site mutant (PAR2S37P). Receptors were co-expressed with TF where indicated. ND, not determined.
