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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Pain. 2008 Mar 28;138(3):514–524. doi: 10.1016/j.pain.2008.01.029

Figure 3.

Figure 3

Effects of systemic (i.p.) PBN or TEMPOL post-treatment on capsaicin-induced hyperalgesia. A,D Time course of PBN or TEMPOL effects on primary hyperalgesia. B,E Time course of PBN or TEMPOL effects on secondary hyperalgesia. C,F The dose response of PBN or TEMPOL on secondary hyperalgesia 2 hr after i.d. capsaicin injection and 30 min post ROS scavenger. Asterisks (*), p ≤ 0.05 (n=6), indicate values significantly different from corresponding values in the vehicle treated group according to Duncan’s post hoc test after two-way repeated ANOVA. Arrowheads indicate time of capsaicin injection. Downward arrows indicates time of tested compound (PBN, TEMPOL, or saline) injection.