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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: J Periodontol. 2008 Aug;79(8):1480–1490. doi: 10.1902/jop.2008.070624

Figure 3.

Figure 3

Periodontal defects worsened with age in the periostin-null mouse. A) Normal periodontal development and homeostasis in the control mouse. B) In the periostin-null mouse, molar teeth develop normally as reflected in the 7-day image. However, significant periodontal changes occur after the teeth erupt and start to sustain a normal occlusal load. The periodontal abnormalities can be detected radiographically at 3, 5, and 7 months, demonstrating a tendency to worsen with age. C and D) Micro-CT visualization of the periodontal tissues confirms the presence, extent, and severity of these defects (red arrows) and clearly accentuates the dramatic periodontal difference that results from a complete lack of periostin expression. In addition, notice the complete obliteration of the incisor pulp chamber (green arrow).