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Incisal reduction of the lower incisor rescues the phenotype. A) The hypofunction condition was created by taking one mandibular incisor of the periostin-null mice out of occlusion by trimming the incisal edge weekly for 3 months starting at 10 days. B) The contralateral incisor was left intact to be used as an internal control. Arrows denote normal anatomy in A and altered anatomy in B.
