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C deamination motif profile of human cell lysates
|
Tonsil
|
Ramos, NE
|
HeLa, NE
|
||
|---|---|---|---|---|
| NEa | S100 | |||
| Mutant frequency (× 10–2)b | 1.7 ± 0.7 | 3.7 ± 0.9 | 6.4 ± 1.2 | 1.3 ± 0.5 |
| No. of sequenced clones | 44 | 48 | 93 | 94 |
| No. of clones with WRC mutations | 16 (36%) | 4 (8%) | 13 (14%) | 1 (1%) |
| No. of clones with CCC108 mutation | 18 (41%) | 41 (85%) | 68 (73%) | 29 (30%) |
NE indicates nuclear lysate; S100 indicates cytoplasmic lysate
The background mutant frequency for the gap substrate is 6.5 ± 2 × 10–4
