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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Neurochem. 2008 Aug 8;107(3):589–601. doi: 10.1111/j.1471-4159.2008.05615.x

Fig. 2.

Fig. 2

Inwardly rectifying K+ currents in astrocytes are mediated by Kir4.1: (a) Voltage-ramps were used to elicit currents in astrocytes isolated from wildtype (WT,1) and Kir4.1 knockout (KO,2) animals. Only wildtype recordings showed any significant inward currents. (b) Using voltage step protocols, wildtype astrocytes showed pronounced inward currents with characteristic inactivation at negative potentials. Inward currents were completely absent in astrocytes from Kir4.1 knockout animals. (c) Astrocytes cultured from knock-out animals demonstrated a near 5-fold increase in input resistance. (d) Resting membrane potential is significantly depolarized in astrocytes cultured from knock out animals (*p < 0.05). [With permission from Olsen et al. 2006].