Figure 2.

Summary of rates of transmission of human prions to transgenic and wild-type mice. Brain homogenate from patients with neuropathologically confirmed (a) kuru, (b) iatrogenic CJD, (c) sporadic CJD and (d) variant CJD were inoculated intra-cerebrally into transgenic mice homozygous for a human PrP 129V transgene array and murine PrP null alleles (Prnp^o/o) designated Tg(HuPrP129V^+/+ Prnp^o/o)-152 mice (129VV Tg152 mice; Collinge et al. 1995), and into wild-type FVB/NHsd mice (genotype Prnp^a). The number of prion disease isolates examined is designated below each schematic patient. Attack rate is defined as the total number of both clinically affected and sub-clinically infected mice as a proportion of the number of inoculated mice. In mice that were asymptomatic, sub-clinical prion infection was assessed by immunoblotting and/or immunohistochemical examination of brain. Primary data are described in references (Collinge et al. 1995, 1996; Hill et al. 1997; Wadsworth et al. 2004, 2008).