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. Author manuscript; available in PMC: 2008 Nov 8.
Published in final edited form as: J Gene Med. 2006 Mar;8(3):298–305. doi: 10.1002/jgm.835

Figure 3.

Figure 3

In vivo evaluation of the LacZ overlapping vectors in skeletal muscle. The TA muscles of BL6 male mice were infected with 5 × 108 vg particles of each indicated AAV virus. LacZ expression was examined 6 weeks later by histochemical staining. (A) Representative photomicrographs following AV.LacZ infection or AV.LacZ.Upstream and AV.LacZ.Downstream co-infection, respectively. Scale bar: 100 μm. (B) Morphometric quantification of transduction efficiency. Positive myofibers were not scored for the staining intensity. Asterisk, transduction efficiency of AV.LacZ is significantly higher than that of the LacZ overlapping vectors of the same AAV serotype. Cross, transduction efficiency of the AAV-6 overlapping vectors is significantly higher than that of the AAV-5 intact gene vector. N = 4 for each group