TABLE 2.
Characteristics of mdx mice and mdx EDL muscles infected by AV.ΔR4
| EDL characteristics at harvest | ||||||
|---|---|---|---|---|---|---|
| AAV | Na | Age at infection | Age at harvest | Weight (mg) | CSA (mm2)b | Transduction (%) |
| AV.AP | 5 | 47 days (7 wk) | 158 days (5 m) | 14.32 ± 0.82 | 2.81 ± 0.16 | 55.88 ± 2.51d |
| AV.ΔR4 | 5 | 47 days (7 wk) | 158 days (5 m) | 13.95 ± 0.79 | 2.74 ± 0.15 | 57.68 ± 4.29d |
| No infection | 4 | N/Ac | 374 days (12 m) | 14.05 ± 0.72 | 2.86 ± 0.12 | N/Ac |
| AV.ΔR4 | 4 | 276 days (9 m) | 374 days (12 m) | 14.73 ± 0.81 | 3.08 ± 0.15 | 31.77 ± 2.20e |
a
Study was performed in paired legs. The left EDL muscle was infected with AV.ΔR4, the right EDL muscle of the same mouse was either infected with AV.AP or not infected with AAV.
b
Cross-sectional area (calculated according to fiber length).
c
Not applicable.
d
There was no statistical difference in transduction efficiency between AV.AP and AV.ΔR4.
e
AV. ΔR4 transduction efficiency in 9-month-old mdx EDL was significantly lower than that in 7-week-old mdx EDL.