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. Author manuscript; available in PMC: 2008 Nov 8.
Published in final edited form as: Hum Mol Genet. 2006 Oct 15;15(SPEC):R253–R261. doi: 10.1093/hmg/ddl180

Figure 3.

Figure 3

Mosaic dystrophin expression in heterozygous mdx mice protects the heart from stress-induced cardiomyopathy. (A) Dystrophin expression in the heart of heterozygous female mice. Top and bottom panels depict regions of low and high dystrophin expression, respectively. Scale bar: 100 μm. (B) Quantification of sarcolemma damage (EBD positive area) in the hearts of different mouse strains following β-isoproterenol challenge. (C) Correction of hemodynamic defect in heterozygous mice. Bar graph shows the dP/dt maximal. Asterisk denotes results in mdx were significantly different from these in BL10 or heterozygous mice. EBD, Evans blue dye; Hetero, heterozygous mice. Adapted from Yue et al. (2004) Hum. Mol. Genet., 13, 1669.