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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Cell Metab. 2008 Oct;8(4):310–317. doi: 10.1016/j.cmet.2008.07.008

Figure 4.

Figure 4

GLUT4 expression is reduced and Insulin signaling is impaired in Cavin null mice. After insulin injection (i.p. 0.75 U/kg), animals were sacrificed and whole cell lysates of wild type (Cavin+/+) and Cavin knockout mice (Cavin−/−) (16 weeks old strain-matched males) from adipocyte, muscle and liver tissues were prepared in RIPA buffer. Representative western blots and quantitative bar graphs are shown for the detection of (A) GLUT4, (B) IR-beta protein levels and (C) total Akt and Akt S473 phosphorylation levels. The statistical values are displayed as means and SE of 3 independent experiments. (*P < 0.05, **P < 0.01, ***P < 0.001).