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OCCM/PLGA implants promote mineral formation in vivo. At 3 and 6 weeks, mineralization was noted only in implants retrieved from SCID mice receiving OCCM/PLGA scaffolds, whereas SV-F and SV-PDL/PLGA implants failed to support mineralization. Multinuclear macrophages (arrow) were seen on the surfaces of all PLGA scaffolds. This is a representative experiment, with similar results noted on two occasions. (Hematoxylin and eosin staining, 20× original magnification.)
