Table 3. Associations of rs174548 (FADS1) with concentrations and ratios between the concentrations of matching pairs of glycerophospholipid species.
| enumerator | denominator | mean | ncases | p-value | estimate | explained variance |
| Single metabolites (four double bonds) | ||||||
| PC a C20:4* | 1 | 5.094 | 284 | 5.3×10−7 | −0.293 | 8.58% |
| PC aa C34:4 | 1 | 3.249 | 284 | 3.3×10−3 | −0.174 | 3.04% |
| PC aa C36:4 | 1 | 399.407 | 284 | 4.5×10−8 | −0.318 | 10.11% |
| PC aa C38:4 | 1 | 209.050 | 284 | 4.9×10−6 | −0.268 | 7.17% |
| PC ae C36:4 | 1 | 35.160 | 284 | 1.7×10−3 | −0.186 | 3.46% |
| PC ae C38:4 | 1 | 30.117 | 284 | 1.4×10−4 | −0.224 | 5.03% |
| PE aa C38:4 | 1 | 5.357 | 284 | 0.13 | −0.090 | 0.81% |
| PI aa C38:4* | 1 | 27.025 | 284 | 0.012 | −0.149 | 2.22% |
| Single metabolites (three double bonds) | ||||||
| PC a C20:3* | 1 | 2.461 | 208 | 0.86 | −0.013 | 0.02% |
| PC aa C34:3 | 1 | 30.751 | 284 | 0.21 | 0.075 | 0.56% |
| PC aa C36:3 | 1 | 250.496 | 284 | 0.56 | 0.035 | 0.12% |
| PC aa C38:3 | 1 | 123.002 | 284 | 0.66 | −0.027 | 0.07% |
| PC ae C36:3 | 1 | 19.697 | 284 | 0.17 | 0.081 | 0.66% |
| PC ae C38:3 | 1 | 10.641 | 284 | 0.74 | 0.020 | 0.04% |
| PE aa C38:3 | 1 | 1.623 | 132 | 0.92 | −0.009 | 0.01% |
| PI aa C38:3* | 1 | 7.791 | 221 | 0.077 | 0.120 | 1.43% |
| Ratios between metabolite concentrations | ||||||
| PC a C20:4* | PC a C20:3* | 2.224 | 208 | 2.9×10−8 | −0.374 | 13.98% |
| PC aa C34:4 | PC aa C34:3 | 0.107 | 284 | 4.2×10−7 | −0.295 | 8.72% |
| PC aa C36:4 | PC aa C36:3 | 1.613 | 284 | 2.4×10−22 | −0.535 | 28.62% |
| PC aa C38:4 | PC aa C38:3 | 1.708 | 284 | 2.1×10−17 | −0.476 | 22.66% |
| PC ae C36:4 | PC ae C36:3 | 1.832 | 284 | 7.3×10−8 | −0.313 | 9.81% |
| PC ae C38:4 | PC ae C38:3 | 2.888 | 284 | 9.7×10−9 | −0.333 | 11.07% |
| PE aa C38:4 | PE aa C38:3 | 3.693 | 132 | 0.013 | −0.216 | 4.64% |
| PI aa C38:4* | PI aa C38:3* | 3.582 | 221 | 1.5×10−8 | −0.370 | 13.69% |
Association of SNP rs174548 (FADS1) with concentrations and ratios between the concentrations of matching pairs of glycerophospholipid species with three- (denominator) and four-fold (enumerator) unsaturated carbon bonds in their fatty acid side chains; in cases where alternative assignments of the metabolites are possible, these are indicated by a ‘*’; reported are the mean (µM), the number of cases for which metabolite concentrations were obtained (ncases), the p-value of the association, the regression coefficient using an additive genetic model (estimate), and the proportion of the observed variance that can be explained by including the genetic polymorphism in the additive genetic model.