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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Curr Opin Cell Biol. 2008 Jun 24;20(5):551–556. doi: 10.1016/j.ceb.2008.05.005

Figure 1. Model for common pathways in mechanotransduction.

Figure 1

Multiple types of mechanical stimuli may trigger conformational activation of low affinity integrins, leading to increased binding to ECM proteins and subsequent activation of signaling pathways. This model may explain why very different types of mechanical stimuli share responses such as FAK and src activation.