TABLE 4.
IL-6/STAT3 Dependent Transcriptome Upregulated in Pediatric Crohn's Disease
| Fold Change |
|||||
|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Cytoband | CD | CD TR | UC |
| Immune and Inflammatory Mediators | |||||
| C4A | Complement Component 4A | 6p21.3 | 3.6 | 4.7 | 7.9 |
| C4B | Complement Component 4B | 6p21.3 | 3.6 | 4.7 | 7.9 |
| C4BPA | Complement Component 4-Binding Protein Alpha | 1q32 | 2.1 | 4.2 | 13.6 |
| C4BPB | Complement Component 4-Binding Protein Beta | 1q32 | 1.8 | 3.8 | 12.1 |
| CD38 | CD38 Antigen | 4p15 | 2.6 | 2.7 | 4.8 |
| CD74 | CD74 Antigen | 5q32 | 2.3 | 3.2 | 4.3 |
| FCER1G | Fc Fragment IgE Receptor 1 Gamma | 1q23 | 4.1 | 6.1 | 7.2 |
| GALNAC4S-6ST | B-cell Rag Associated Gene | 10q26 | 2.4 | 3.8 | 5.3 |
| HCK | Hemopoietic Cell Kinase | 20q11-q12 | 2.7 | 3.5 | 3.5 |
| HLA-DQB1 | Major Histocompatibilty Complex | 6p21.3 | 1.9 | 2.9 | 3.8 |
| HLA-DRA | Major Histocompatibilty Complex | 6p21.3 | 2.5 | 3.7 | 4.8 |
| HLA-DRB1 | Major Histocompatibilty Complex | 6p21.3 | 2.0 | 2.9 | 3.4 |
| HLA-DRB3 | Major Histocompatibilty Complex | 6p21.3 | 2.0 | 2.9 | 3.4 |
| INDO | Indoleamine 2,3 Dioxygenase | 8p12-p11 | 6.2 | 9.4 | 6.5 |
| LCP2 | Lymphocyte Cytosolic Protein-2 | 5q33.1-qter | 2.9 | 4.5 | 5.5 |
| MS4A2 | Membrane-Spanning 4 Domain Fc IgE Fragment | 11q13 | 2.3 | 2.7 | 3.1 |
| NCF2 | Neutrophil Cytosolic Factor 2 | 1q25 | 3.8 | 4.7 | 5.8 |
| SEMA4D | Semaphorin 4D | — | 1.8 | 1.9 | 3.0 |
| Chemokines, Cytokines and Growth Factors | |||||
| CCL11 | Chemokine Ligand 2 (CC Motif) | 17q21.1-q21.2 | 4.2 | 11.0 | 7.9 |
| CSF1R | Colony Stimulating Factor 1 Receptor | 5q33.2-q33.3 | 2.3 | 3.6 | 4.2 |
| CSF2RA | Colony Stimulating Factor 2 Receptor Alpha | Xp22.32 | 1.7 | 1.7 | 2.1 |
| CXC3R1 | Chemokine Receptor 3 | Xq13 | 3.1 | 4.4 | 6.2 |
| CXCL1 | Chemokine Ligand 1 | 4q12-q13 | 8.9 | 13.3 | 22.1 |
| CXCL2 | Chemokine Ligand 2 | 4q12-q13 | 3.0 | 4.0 | 5.2 |
| CXCL3 | Chemokine Ligand 3 | 4q12-q13 | 3.6 | 4.1 | 7.1 |
| CXCL5 | Chemokine Ligand 5 | 4q12-q13 | 15.0 | 6.6 | 26.3 |
| CXCL6 | Chemokine Ligand 6 | 4q12-q13 | 10.3 | 13.5 | 31.6 |
| CXCL9 | Chemokine Ligand 9 | 4q21 | 7.0 | 10.1 | 7.4 |
| CXCL10 | Chemokine Ligand 10 | 4q21 | 3.6 | 5.8 | 3.8 |
| CXCL11 | Chemokine Ligand 11 | 4q21.2 | 7.4 | 12.7 | 8.3 |
| CXCL12 | Chemokine Ligand 12 | 10q11.1 | 1.7 | 3.3 | 2.5 |
| IL-6 | Interleukin 6 | 7p21 | 7.3 | 3.5 | 6.2 |
| IL-8 | Interleukin 8 | 4q12-q13 | 5.7 | 4.3 | 7.6 |
| IL-8RB | Interleukin 8 Receptor Beta | 2q35 | 5.4 | 2.6 | 6.3 |
| IL-12RB1 | Interleukin 12 Receptor Beta 1 | 19p13.1 | 1.7 | 2.0 | 2.7 |
| IL-2RB | Interleukin 2 Receptor Beta | 22q11.1-q13 | 2.2 | 2.5 | 3.9 |
| OSMR | Oncostatin M Receptor | — | 1.9 | 2.7 | 5.4 |
| Cancer and Cell Proliferation/STAT1 and 3 | |||||
| FGR | Gardner-Rasheed Feline Sarcoma Viral Oncogene | 1p36.1-p36.2 | 3.1 | 3.6 | 4.3 |
| JAK2 | Janus Kinase 2 | 9p24 | 1.8 | 2.3 | 2.9 |
| KIT | V-kit Hardy-Zuckerman Feline Sarcoma Viral Oncogene |
4q12 | 2.7 | 5.2 | 6.0 |
| PIM2 | Oncogene PIM2 | X Chrom. | 2.6 | 3.1 | 6.7 |
| PRAP1 | Proline Rich Acidic Protein 1 | 10q26 | 0.31 | 0.32 | 0.15 |
| PTPRG | Protein-Tyrosine Phosphatase Receptor Gamma | 3p14.2 | 1.6 | 2.1 | 3.1 |
| VAV1 | Vav1Oncogene | 19p13.3-p13.2 | 1.7 | 1.9 | 2.3 |
| STAT1 | Signal Transducer and Activator of Transcription 1 | 2q32.2-q32.3 | 2.0 | 1.8 | 2.2 |
| STAT3 | Signal Transducer and Activator of Transcription 3 | 17q21 | 1.2 | 1.3 | 1.5 |
| ECM/Tissue Remodeling/Cell Adhaesion | |||||
| ANPEP | Alanyl aminopeptidase | 15q25-q26 | 0.35 | 0.19 | 0.09 |
| CTSK | Cathespin K | 1q21 | 2.3 | 3.8 | 6.0 |
| HAS2 | Hyaluronon Synthase 2 | 8q24.12 | 2.2 | 5.5 | 6.0 |
| ICAM1 | Intercelleular Adhesion Molecule 1 | 19p13.3-p13.2 | 2.2 | 2.4 | 2.9 |
| ITGB2 | Integrin B2 | 21q22.3 | 2.6 | 3.6 | 4.5 |
| MMP10 | Matrix Metalloproteinase 10 | 11q22.3-q23 | 8.3 | 7.9 | 95.0 |
| PECAM1 | Platelet-Endothelial Cell Adhesion Molecule 1 | 17q23 | 1.9 | 2.6 | 3.8 |
| Metabolic Pathways and Transcription Factors | |||||
| ACOT8 | Acyl-CoA Thioesterase 8 | 20q13.1 | 0.63 | 0.45 | 0.36 |
| CYP2C9 | Cytochrome P450 Subfamily IIC | 10q24 | 0.32 | 0.26 | 0.13 |
| CYP2C18 | Cytochrome P450 Subfamily IIC | 10q24 | 0.51 | 0.48 | 0.44 |
| MITF | Microphthalmia-Associated Transcription Factor | 3p14.1-p12.3 | 1.8 | 2.5 | 3.0 |
| NMU | Neuromedin U | Chrom. 4 | 1.6 | 2.2 | 2.8 |
| NOX1 | NADPH Oxidasae | Xq22 | 1.7 | 1.9 | 1.7 |
| RGS18 | Regulator of G Protein Signaling 18 | 1q31.2 | 2.8 | 4.8 | 5.5 |
| SERPINA1 | Proteinase Inhibitor I | 14q32.1 | 1.9 | 3.1 | 3.5 |
| STAP2 | Signal Transducing Adapter Protein 2 | Chrom. 19 | 0.55 | 0.41 | 0.27 |
| WARS | Tryptophanyl-tRNA Synthetase | 14q32.31 | 2.8 | 2.8 | 3.6 |
| XBP1 | X-Box Binding Protein 1 | 22q12 | 1.9 | 2.4 | 3.9 |