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Schematic diagram of pTH-NFHth/ires/aadc. This vector contains a herpes simplex virust type 1 (HSV-1) a sequence (contains the packaging site) and an HSV-1 origin of DNA replication (oriS) to support replication and packaging of the vector into HSV-1 particles. The transcription unit in the vector contains the TH-NFH promoter, a human TH cDNA, an internal ribo-some entry site (ires), and a human AADC cDNA. TH, tyrosine hydroxylase; AADC, aromatic amino acid decarboxylase.
