Table 1.

Antiplasmodial activity.

	Strain/Experimental IC50 (nM)
Compound	HB3	Dd2	SI1	GCO3	FCB	SI1
CQ	13.5	140	10.4	16.0	170	10.6
4a	29.2	129	4.43	118	146	1.24
4b	27.3	56.3	2.06	64.8	73.7	1.14
4c	72.5	170	2.34	139	189	1.36
4d	46.0	103	2.25	68.7	97.3	1.42
4e	82.8	269	3.25	129	216	1.67
5a	27.3	31.2	1.14	37.7	52.7	1.40
5b	21.2	28.1	1.33	27.6	49.1	1.78
5c	24.1	84.6	3.52	87.4	156	1.78
5d	15.7	43.4	2.76	55.2	66.8	1.21
5e	62.9	274	4.36	175	263	1.50
6a	187	128	0.68	96.6	186	1.92
6b	44.1	99.8	2.26	42.4	104	2.45
7a	716	882	1.23	517	1060	2.05
7b	1314	2550	1.94	1512	2225	1.47
16a	26.3	80.0	3.04	40.6	113	2.78
17a	25.5	51.8	2.03	32.0	57.6	1.80
16b	27.8	76.1	2.74	26.1	110	4.21
17b	31.3	75.7	2.42	19.5	66.0	3.89

The experimental IC₅₀'s are averages of two separate determinations each conducted in triplicate.

¹The selectivity index (SI) is the ratio of the IC₅₀ for the resistant versus the sensitive strain (Dd2/HB3, 4^th column; FCB/GCO3, 7^th column).