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. Author manuscript; available in PMC: 2009 Jun 24.
Published in final edited form as: JAMA. 2008 Jun 25;299(24):2877–2883. doi: 10.1001/jama.299.24.2877

Table 2.

Genes showing greatest differences in family 21 and also across all individuals, showing a high representation of immunological mediators among these genes.

Gene name Gene function
AIM2a Interferon gamma inducible transcript
CSF3Ra Colony stimulating factor 3 receptor
HOXA5 Hox gene
PTK6 Protein tyrosine kinase
ERCC3 Helicase with excision-repair functions
LMO2a Role in erythropoiesis and in T-cell leukemogenesis
SYKa Spleen-tyrosine kinase
IL10a Cytokine
BIRC4 Apoptosis inhibitor
IL16a Cytokine
LCN2a Protein associated with neutrophil gelatinase
TRIP6 Regulates lysophosphatidic acid induced cell migration
EMR3a Myeloid-myeloid interactions during immune and inflammatory responses
a

Genes that play a role as immunological modulators