Table 3.
Mixed-model ANCOVA results for regional volume by hemisphere with “sex” as an among-subject factor and transformation template (native, Tal, Tal50, MNI305, or IA38) as a within-subject factor. Covariables were age and native total brain volume (gray plus white matter); p values are provided when significant, “ns” when not significant; F values are provided for all regions in parentheses
Region | Method Effect | Method by Sex Interaction | Method by Age Interaction | ||||
---|---|---|---|---|---|---|---|
Gray | White | Gray | White | Gray | White | ||
Cerebral Hemisphere | Left | <0.001 (7.73) | 0.001 (4.85) | <0.001 (7.51) | 0.004 (4.12) | <0.001 (4.38) | 0.003 (2.69) |
Right | <0.001 (6.16) | <0.001 (7.67) | <0.001 (7.16) | 0.002 (4.60) | <0.001 (3.81) | <0.001 (4.02) | |
| |||||||
Frontal Lobe | Left | <0.001 (7.18) | 0.002 (4.47) | 0.009 (3.54) | ns (1.70) | <0.001 (4.06) | 0.022 (2.08) |
Right | 0.001 (4.73) | <0.001 (5.91) | 0.008 (3.62) | 0.041 (2.57) | <0.001 (3.24) | 0.002 (2.86) | |
| |||||||
Parietal Lobe | Left | ns (1.00) | ns (1.10) | 0.048 (2.47) | ns (1.60) | ns (0.74) | ns (0.95) |
Right | ns (1.36) | 0.020 (3.02) | ns (2.43) | ns (1.39) | ns (1.00) | ns (1.61) | |
| |||||||
Temporal Lobe | Left | 0.021 (3.00) | ns (1.09) | 0.014 (3.24) | ns (1.56) | 0.039 (1.91) | ns (0.69) |
Right | 0.016 (3.18) | ns (1.22) | 0.006 (3.78) | ns (1.35) | ns (1.75) | ns (0.70) | |
| |||||||
Occipital Lobe | Left | ns (0.82) | ns (0.54) | ns (1.02) | ns (0.80) | ns (0.38) | ns (0.30) |
Right | ns (0.76) | ns (0.30) | ns (1.42) | ns (0.43) | ns (0.40) | ns (0.19) | |
| |||||||
Cingulate Gyrus | Left | ns (0.51) | ns (1.06) | ns (0.22) | ns (0.41) | ns (0.61) | ns (0.88) |
Right | 0.038 (2.62) | 0.047 (2.62) | ns (1.07) | ns (0.37) | ns (1.16) | ns (1.22) | |
| |||||||
Insula | Left | 0.011 (3.42) | ns (0.37) | ns (1.32) | ns (0.10) | ns (1.48) | ns (0.20) |
Right | 0.009 (3.53) | ns (0.67) | ns (1.67) | ns (0.26) | ns (1.59) | ns (0.35) | |
| |||||||
Hippocampus | Left | ns (1.03) | ns (1.57) | ns (0.69) | |||
Right | ns (1.18) | ns (1.46) | ns (0.69) | ||||
| |||||||
Corpus Callosum | ns (1.40) | ns (0.78) | ns (0.71) |