. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: J Pharmacol Exp Ther. 2008 Jun 23;326(3):983–990. doi: 10.1124/jpet.108.138073

TABLE 2.

Biliary excretion index (BEI) and in vitro intrinsic Cl_biliary of ARBs and statins in sandwich-cultured hepatocytes from WT and TR⁻ rats. Data represent mean ± SEM (n = 3–4 livers)

Compound	BEI (%)		In vitro intrinsic Cl_biliary (ml/min/kg)^a
Compound	WT	TR⁻	WT	TR⁻
E2–17βG	18.4 ±3.9	0.378 ±0.378	17.8 ±0.4	0.363 ±0.363
Olmesartan	14.7 ±0.5	7.05 ±0.93	1.72 ±0.25	0.931 ±0.167
Valsartan	18.9 ±2.6	1.63 ±1.33	3.24 ±0.51	0.406 ±0.341
Pravastatin	43.4 ±2.3	10.7 ±3.4	4.43 ±0.75	1.13 ±0.33
Rosuvastatin	44.9 ±6.1	20.6 ±3.9	46.1 ±0.4	21.2 ±6.0
Pitavastatin	19.9 ±1.4	6.54 ±3.38	34.6 ±3.1	10.4 ±5.4

In vitro intrinsic Cl_biliary values were calculated according to Equation (2) based on a 10-min incubation at concentrations of 1 μM for E2–17βG and 5 μM for all other compounds.