Figure 6.

Early control of MCMV infection is PKC-θ–independent. (A) Age-matched WT and PKC-θ^−/− mice were infected intraperitoneally with 5 × 10⁵ pfu of MCMV. Three days after infection, spleen and liver viral loads were determined by plaque assay. Results are representative of 3 independent experiments. (B) Age-matched WT and PKC-θ^−/− mice were infected intraperitoneally with 5 × 10⁵ pfu of MCMV. At 36 hours and 60 hours after infection, splenocytes were analyzed ex vivo for intracellular IFN-γ content by FACS, gating on NK1.1⁺CD3⁻CD19⁻ NK cells.