Table 4.
The genotype frequencies of four polymorphisms of CYP1B1 gene between Chinese uterine leiomyoma patients and controls
| SNP | Genotype | Cases n = 100 (%) | Control n = 110 (%) | Adjusted OR (95% CI) | P-value |
|---|---|---|---|---|---|
| Arg48Gly | CC | 70 (70.0) | 71 (64.5) | 1.00 (Ref.) | – |
| CG | 29 (29.0) | 39 (35.5) | 1.33 (0.74–2.38) | 0.342 | |
| GG | 1 (1.0) | 0 (0.0) | 0.50 (0.42–0.59) | 0.316 | |
| CG+GG | 30 (30.0) | 39 (35.5) | 1.28 (0.72–2.29) | 0.401 | |
| Ala119Ser | GG | 57 (57.0) | 63 (57.3) | 1.00 (Ref.) | – |
| GT | 40 (40.0) | 45 (40.9) | 1.02 (0.58–1.78) | 0.950 | |
| TT | 3 (3.0) | 2 (1.8) | 0.60 (0.10–3.74) | 0.584 | |
| GT+TT | 43 (43.0) | 47 (42.7) | 0.99 (0.57–1.71) | 0.968 | |
| Leu432Val | CC | 71 (71.0) | 70 (63.6) | 1.00 (Ref.) | – |
| CG | 29 (29.0) | 40 (36.4) | 1.40 (0.78–2.50) | 0.257 | |
| Asp449Asp | CC | 76 (76.0) | 71 (64.5) | 1.00 (Ref.) | – |
| CT | 23 (23.0) | 38 (34.5) | 1.77 (0.96–3.26) | 0.066 | |
| TT | 1 (1.0) | 1 (1.0) | 1.07 (0.07–17.44) | 0.962 | |
| CT+TT | 24 (24.0) | 39 (35.5) | 1.74 (0.95–3.18) | 0.070 |
OR Odds ratio, 95% CI 95% confidence interval, Ref. reference category