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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Biochemistry. 2008 Aug 29;47(38):10084–10098. doi: 10.1021/bi8003928

Figure 5. NHERF2 PDZ domains bind the CFTR C-terminus with high affinity.

Figure 5

(A and B) Fluorescence anisotropy data were obtained for 30 nM F*-CFTR10 (filled diamonds) or a scrambled control peptide F*C-SCR6 (open diamonds) in the presence of increasing concentrations of N2P1 (A) or N2P2 (B). Single binding-site fits (solid lines) are shown for N2P1 (A; Kd = 323 ± 32 nM) and N2P2 (B; Kd = 232 ± 46 nM). Values shown are mean ± SD, n=3.

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