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. Author manuscript; available in PMC: 2008 Nov 11.

Published in final edited form as: Int J Oncol. 2007 Dec;31(6):1293–1300.

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Structure of RV and its effects on proliferation and cell cycle changes (B-F) in PC-3 cells. (A) Structure of RV. (B) Dose-dependent effects (2-day treatment) of RV on PC-3 cell growth (mean of 2-3 experiments). (C) Time-dependent effects of RV on PC-3 cell proliferation (mean of 2-3 experiments). (D) Effects of RV on cell cycle phase distribution. (E) Flow analysis showing formation of polyploidal cells (with ≥4N DNA) upon treatment by RV. (F) Quantitative determination of hyperploid cells with >4N DNA in RV-treated cells.

Structure of RV and its effects on proliferation and cell cycle changes (B-F) in PC-3 cells. (A) Structure of RV. (B) Dose-dependent effects (2-day treatment) of RV on PC-3 cell growth (mean of 2-3 experiments). (C) Time-dependent effects of RV on PC-3 cell proliferation (mean of 2-3 experiments). (D) Effects of RV on cell cycle phase distribution. (E) Flow analysis showing formation of polyploidal cells (with ≥4N DNA) upon treatment by RV. (F) Quantitative determination of hyperploid cells with >4N DNA in RV-treated cells.