Figure 7.
Estrous cycle time courses when the actions of inhibin are included in the model. (A) The time courses of inhibin (Ib) and GnRH are imposed on the system to qualitatively match experimental measurements. (B) The FSHb level during the first two days of the cycle is suppressed by inhibin action on FSHp, accentuating the proestrus surge. (C) The blood FS level now exhibits two small peaks, rather than the single large peak that it did without inhibin action. (D) The FSH protein time course, with two clear peaks on proestrus, is now a much better fit to experimental measurements.