Skip to main content
. Author manuscript; available in PMC: 2008 Nov 11.
Published in final edited form as: J Biol Chem. 2005 Feb 23;280(18):17593–17600. doi: 10.1074/jbc.M500163200

Fig. 4. Effect of OPLS on the Immunogenicity of rFVIII.

Fig. 4

a, total mean (bars) and individual (open symbols) antibody titers against rFVIII as determined by antibody capture ELISA in hemophilia A mice immunized with rFVIII (○) or rFVIII·OPLS (△). b, total mean (bars) and individual (open symbols) antibody titers at 6 weeks as determined by antibody capture ELISA in hemophilia A mice immunized with rFVIII, rFVIII·OPLS, rFVIII + PC, or rFVIII + PA. c, mean (bars) and individual (open symbols) inhibitory titers at 6 weeks as determined by the Nijmegen modification of the Bethesda assay in hemophilia A mice immunized with rFVIII, rFVIII·OPLS, rFVIII + PC, or rFVIII + PA. Statistical analysis was by analysis of variance followed by post hoc Dunnet's test (*, p < 0.05).