Fig. 3.

Response of Myc-driven lymphomas to cyclophosphamide. (A) Kaplan–Meier plots indicating survival of mice bearing 10 independent myc lymphomas after treatment with a single (300 mg/kg ip) dose of cyclophosphamide (AF40, AG36, AH29, AH44, AH66, AF47, AH15, AH21, AI18, and AI71). P value (log rank analysis) for vehicle vs. cyclophosphamide is indicated. Treatment was initiated when tumors were palpable and survival is indicated from day of treatment (arrow, day 0). Overall median survival (time elapsed from day of treatment until 50% of the mice remained alive) with treatment was 98 days versus 3 days without (Table S2). (B) Survival of mice with five independent myc/bcl-2 lymphomas (#9, 10, 12, 16, and 30) treated similarly with cyclophosphamide. Median survival with treatment was 32 days and 12 days without (Table S2). P value as for A.