Fig. 6.
Cocaine- and amphetamine-regulated transcript (CART) improves mitochondrial dysfunction and neuronal viability after oxygen-glucose deprivation (OGD). (A) CART improves neuronal survival as determined by the reduction of MTT by mitochondrial dehydrogenases (n = 7 per group, *P < 0.05 compared with control; #P < 0.05 compared with OGD alone). (B) CART decreases OGD-induced cell death as determined by PI/calcein staining at 24 h after 2 h OGD (n = 6 per group, *P < 0.05 compared with control; #P < 0.05 compared with OGD alone).