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Genomic variation arising during ES cell culture. The parental cells (green) segregate variants (yellow, orange, and red). Clones with major chromosomal changes (red) cannot be transmitted into the mouse germ line and typically exhibit trisomies or multiple deletions or duplications. Some clones have a few small (1- to 2-Mb) CNVs that do not affect germ-line transmission. These CNVs may be transmitted into the mouse germ line along with an engineered allele.
