Table 1. Serum biochemical analytes (median and 2.5^th–97.5^th percentiles interval) measured in aged 4–8 months C57BL/6J, 129SV/EV and C3H/HeJ mouse strains (n = 90).

Analyte	Mouse Strain						Inter strain differencesa
	C57BL/6J		129SV/EV		C3H/HeJ
	Male	Female	Male	Female	Male	Female
GLU mmol/L	7.4 b	7.1	6.7	6.6	7.5 b	6.6	129SV/EV p<0.05
	5.6–9.1	5.2–12.2	4.1–9.9	4.7–8.4	6.3–8.6	5.6–8.3
LPS U/L	901	1177 b	991	1090	969	1057
	649–1646	788–1624	689–1201	777–1419	536–1372	634–1541
TAG mmol/L	2.2 c	1.2	1.8	1.6	2.3	2.3	C3H/HeJ p<0.001
	1.1–2.9	0.6–1.8	0.9–4.5	0.7–4.8	1.7–6.0	1.0–3.8
Chol mmol/L	2.6 b	2.1	3.2	3.1	3.5	3.4	C3H/HeJ p<0.001
	1.8–3.9	1.3–3.4	2.2–5.3	2.1–4.1	2.8–5.2	2.2–3.6
LDH U/L	1888	1837	2430	2240		2067
	1590–2610	843–3150	2212–3150	1752–3150	>2250 b d	1829–2250
CK U/L	327	319	398	544	324	464
	209–635	105–649	138–615	199–964	206–660	204–921
Crea µmol/L	10.2	10.2	12.4	12.4	10.2	10.2
	8.8–13.2	8.8–13.2	8.8–20.5	8.8–20.5	8.8–12.3	8.8–12.4
BUN mmol/L	9.0 b	7.8	10.0 b	7.8	8.3 b	7.5
	7.8–11.5	6.8–10.0	6.8–13.2	6.5–10.3	7.4–12.9	6.6–10.0
UA mmol/L	0.3	0.2	0.2	0.2	0.2	0.2
	0.1–0.6	0.1–0.7	0.1–0.3	0.1–0.3	0.1–0.6	0.1–0.5
GGT U/L	6.9	7	6.8	6.9	7	8.4
	6–8	6–8	6–8	6–8	6–8	6–10
AST U/L	75	91 b	98	104	116	121	C57BL/6J p<0.001
	55–91	51–122	71–201	69–194	67–160	80–172
ALT U/L	61	55	64	63	67	80
	46–70	42–73	45–84	46–114	39–115	56–107
ALP U/L	84	145 c	86	142 b	120	200 c
	67–128	103–217	68–179	97–287	75–137	126–240
t-Bil µmol/L	7.2	7.9	5.9	3.9	9.6	9.6	129SV/EV p<0.05
	5.1–11.9	3.4–14.3	1.7–19.1	1.7–14.3	3.4–11.9	3.4–13.9
c- Bil µmol/L e	0–1.7	0–5.1	0–5.1	0–3.4	0–6.8	0–6.8
CHE U/L	4450	6880 c	5540	7550 c	5350	6790 b
	3870–6130	5660–9770	4440–6830	5870–8620	3690–9790	5420–9560
TP g/L	63	66	61	57	62	53
	47–72	45–83	43–65	48–68	49–74	25–71
Alb g/L	33	34	29	27	31	31
	22–42	20–47	18–31	20–36	22–39	24–41
CRP mg/L e	0–0.7	0–0.7	0–2.8	0–1.4	0–0.7	0–2.3
Na+ mmol/L	179.2	179.8	180.9	178.6	184.4	182.1
	151.0–254.8	149.0–281.4	147.0–253.4	148.0–253.4	151.0–247.8	150.0–245.0
K+ mmol/L	6.6	6.6	8.2	7.9	8.6	8.1	C57BL/6J p<0.05
	5.2–14.5	4.0–14.0	4.9–10.3	5.0–9.5	5.8–13.1	6.0–13.4
Cl− mmol/L	131.1	137.4	128.7	131.1	131.1	132.2
	109.0–179.2	110.0–204.4	106.0–179.2	110.0–184.8	110.0–172.2	110.0–177.8
Ca++ mmol/L	2.4	2.5	2.8	2.8	2.6	2.7	C57BL/6J p<0.05
	2.2–2.6	2.3–3.5	2.3–3.4	2.3–3.0	2.2–2.9	2.3–2.9
Mg++ mmol/L	1.3	1.3	1.2	1.3	1.3	1.3
	1.1–1.7	1.2–1.8	1.0–1.4	0.9–1.4	0.9–1.8	1.0–1.9
PO4 − mmol/L	2.3	2.4	1.9	1.9	2.9	2.9	129SV/EV p<0.05
	2.1–2.7	2.0–3.1	1.4–3.0	1.5–3.1	1.6–3.6	1.8–3.5
Fe++µg/dL	138.0	136.8	181.5	206.5	216.9	191.4	C57BL/6J p<0.001
	102.0–190.4	70.0–184.8	121.0–273.0	111.0–280.7	142.0–334.6	131.0–320.6

^aSignificantly different values in the reported mouse strain vs the other strains.

^{b c}Significantly different intersex mouse strain values: p<0.05 and p<0.001 respectively.

^dAnalyte value above the upper linearity level of the method on undiluted sample.

^emin-max values.