Table 1.
Patohistological, immunohistochemical, and molecular characteristics of renal cell tumors
| Characteristics | CCRCC* | non-CCRCC† | P |
|---|---|---|---|
| Tumor size (cm, mean±SD) | 7.8 ± 3.6 | 6.3 ± 3.5 | 0.299‡ |
| Pathological stage (No.): | |||
| 1 | 13 | 6 | 0.443§ |
| 2 | 9 | 3 | |
| Nuclear grade (No.): | |||
| 1 | 15 | 5 | 0.505§ |
| 2 | 7 | 4 | |
| VEGF (%, mean±SD): | |||
| perimembranous | 27.1 ± 18.9 | 3.3 ± 10 | 0.001‡ |
| diffuse | 31.1 ± 22.1 | 71.7 ± 23.2 | <0.001‡ |
| Ki67 index (%, mean±SD) | 13.4 ± 9.2 | 7.9 ± 5.6 | 0.106‡ |
| NF-κB/p65 (histo-score, mean±SD): | |||
| nuclear | 103.2 ± 64.9 | 98.4 ± 63.9 | 0.852‡ |
| cytoplasmic | 214.5 ± 58.5 | 225.6 ± 58.1 | 0.637‡ |
| VEGF mRNA (RQ) (median, range)║ | 10.2 (0.3-142.2) | 2.3 (0.05-14.9) | 0.004¶ |
| Number of cases | 22 | 9 |
*Abbreviations: CCRCC – clear cell renal cell carcinoma; VEGF – vascular endothelial growth factor; NF-κB – nuclear factor-κB; SD – standard deviation.
†Papillary renal cell carcinoma, collecting duct carcinoma, and chromophobe carcinoma.
‡t test.
§Pearson χ2 test.
║Relative quantity of VEGF mRNA calculated using ΔΔCT method.
¶Mann-Whitney U-test.