TABLE 4.
Identity and frequencies of SNP haplotypes for the apoH promoter region and results of HBAT association analysis
| Association Results African Americans
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Promoter SNPs
|
GENOA Frequencies
|
HCT
|
DCT
|
||||||||||||
| Haplotype | -1283 | -1218 | -1054 | -758 | -700 | -643 | -627 | -581 | EA | AA | MA | TC | LDL-C | ApoB | ApoE |
| Hap1 | C | G | T | A | C | T | A | A | 0.539 | 0.608 | 0.583 | ns | ns | ns | ns |
| Hap2 | C | G | T | G | A | T | A | A | 0.209 | 0.045 | 0.072 | ns | ns | ns | ns |
| Hap3 | C | G | T | A | C | C | A | A | 0.163 | 0.157 | 0.273 | ns | ns | ns | ns |
| Hap4 | C | A | T | G | A | T | A | A | 0.078 | 0.013 | 0.027 | ns | ns | ns | ns |
| Hap5 | G | G | T | A | C | T | A | A | 0.022 | na | na | na | na | ||
| Hap6 | C | G | T | A | C | T | A | C | 0.068 | ns | ns | ns | ns | ||
| Hap7 | C | G | T | A | C | T | C | A | 0.058 | ns | ns | ns | ns | ||
| Hap8 | C | G | T | A | A | T | A | A | 0.021 | 0.006 | 0.030 | 0.001 | 0.006 | ||
| Hap9 | C | G | G | A | C | T | A | A | 0.013 | ns | 0.022 | ns | ns | ||
HBAT, haplotype-based association test; HCT, hepatic cholesterol transport; DCT, dietary cholesterol transport; ns, not significant (P > 0.05); na, not available; number of informative families <10.